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Enhancement of protease activity involved in modulation of cell mutability by microgravity stress in UVC-irradiated human cells

Takahashi, S.; Zhang, H.C.; Sugaya, S.; Nomura, J.; Kita, K.; Suzuki, N.

Journal of Gravitational Physiology a Journal of the International Society for Gravitational Physiology 8(1): P25-P26

2001

ISSN/ISBN: 1077-9248
PMID: 12638609
Document Number: 531013
It is an intriguing question whether gravity-changing stress modulates human cell mutability. To resolve this problem, it is necessary to determine the cellular events leading to modulation. We previously detected protease activation just after UV (UVC, principally 254 nm wavelength) irradiation followed by hypomutability in cultured human cells. We here investigated whether UV-activated protease activity is affected in human UVAP-1 cells exposed to gravity-changing stress prior to UV irradiation.

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