Neoadjuvant chemotherapy for advanced gastric cancer with para-aortic lymph node metastasis
Uehara, S.; Murabayashi, K.; Kusta, T.; Takahashi, K.; Ogawa, T.; Onishi, H.; Saegusa, S.; Noda, N.; Okanami, Y.; Nakamura, I.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 28(10): 1413-1418
2001
ISSN/ISBN: 0385-0684 PMID: 11681249 Document Number: 529178
Neoadjuvant chemotherapy was applied to patients with advanced gastric cancer and confirmed para-aortic lymph node metastasis. Subjects were 7 patients. The response to the neoadjuvant chemotherapy was a PR in 5 cases, MR in 2 cases for the primary lesion and CR in 2 cases PR in 5 cases for the para-aortic lymph node metastasis. The grades of histological response assessed on the resected specimen were Grade 0 in three cases, Grade 1a in one, Grade 1b in one and Grade 2 in two. While there was no significant difference in survival rate between patient groups with and without neoadjuvant chemotherapy, the 2-year survival rate in patients with neoadjuvant chemotherapy was a good 42.9%, compared with 10% in patients groups without neoadjuvant chemotherapy. It is concluded that a better prognosis can be expected for advanced gastric cancer patients with neoadjuvant chemotherapy.