HIV resistance and tolerability issues in antiretroviral therapy
Idemyor, V.
Journal of the National Medical Association 93(4): 151-153
2001
ISSN/ISBN: 0027-9684 PMID: 12653403 Document Number: 527898
The therapeutic regimens used to treat patients with HIV disease involve a considerable pill burden. Patient adherence to dosing schedules and other factors have been implicated in the therapeutic failure of antiretroviral agents. Alternative medical approaches to HIV disease are problematic for clinicians and scientists because many of these herbal compounds have not been assessed in well-designed research trials. A thorough investigation of alternative therapies by the medical and pharmacological sciences are needed for evaluation against existing therapies.
Document emailed within 1 workday
Related Documents
Vergne, L.; Malonga-Mouellet, G.; Mistoul, I.; Mavoungou, R.; Mansaray, H.; Peeters, M.; Delaporte, E. 2002: Resistance to antiretroviral treatment in Gabon: need for implementation of guidelines on antiretroviral therapy use and HIV-1 drug resistance monitoring in developing countries Journal of Acquired Immune Deficiency Syndromes 29(2): 165-168Vergne, L.; Malonga-Mouellet, G.; Mistoul, I.; Mavoungou, R.; Mansaray, H.; Peeters, M.; Delaporte, E. 2002: Resistance to antiretroviral treatment in Gabon: need for implementation of guidelines on antiretroviral therapy use and HIV-1 drug resistance monitoring in developing countries Journal of Acquired Immune Deficiency Syndromes 29(2): 165-168
Tukei, V.J.; Asiimwe, A.; Maganda, A.; Atugonza, R.; Sebuliba, I.; Bakeera-Kitaka, S.; Musoke, P.; Kalyesubula, I.; Kekitiinwa, A. 2012: Safety and tolerability of antiretroviral therapy among HIV-infected children and adolescents in Uganda Journal of Acquired Immune Deficiency Syndromes 59(3): 274-280
Hamers, R.L.; Wallis, C.L.; Kityo, C.; Siwale, M.; Mandaliya, K.; Conradie, F.; Botes, M.E.; Wellington, M.; Osibogun, A.; Sigaloff, K.C.E.; Nankya, I.; Schuurman, R.; Wit, F.W.; Stevens, W.S.; van Vugt, Mèle.; de Wit, T.F.Rinke.; Mandaliya, K.; Abdallah, S.; Jao, I.; Dolan, M.; Schuurman, R.; Wensing, A.M.; Hamers, R.L.; Sigaloff, K.C.E.; Straatsma, E.; Wit, F.W.; van Vugt, M.; Lange, J.M.; Rinke de Wit, T.F.; Osibogun, A.; Akanmu, S.; Botes, M.E.; Conradie, F.; Ive, P.; Sanne, I.; Wallis, C.L.; Letsoalo, E.; Stevens, W.S.; Hardman, M.; Kityo, C.; Namayanja, G.; Nakatudde, L.; Nankya, I.; Kiconco, M.; Abwola, M.; Mugyenyi, P.; Ndembi, N.; Lyagoba, F.; Kaleebu 2011: HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study Lancet. Infectious Diseases 11(10): 750-759
Newman, H.; Breunig, L.; van Zyl, G.; Stich, A.; Preiser, W. 2014: A qualitative PCR minipool strategy to screen for virologic failure and antiretroviral drug resistance in South African patients on first-line antiretroviral therapy Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology 60(4): 387-391
Boyle, B.A. 2001: Issues in antiretroviral therapy: when to start? Aids Reader 11(2): 66-70
Lesho, E.P.; Gey, D.C. 2003: Managing issues related to antiretroviral therapy American Family Physician 68(4): 675-686
Quigg, M.; Frost, S.D.W.; McDonagh, S.; Burns, S.M.; Clutterbuck, D.; McMillan, A.; Leen, C.S.; Brown, A.J.Leigh. 2002: Association of antiretroviral resistance genotypes with response to therapy--comparison of three models Antiviral Therapy 7(3): 151-157
Tournoud, M.; Etard, J.F.; Ecochard, R.; DeGruttola, V. 2010: Adherence to antiretroviral therapy, virological response, and time to resistance in the Dakar cohort Statistics in Medicine 29(1): 14-32
Toledo, P.V.M.; Carvalho, D.S.d.; Romagnoli, L.; Marcinko, G.; Cunha, C.A.d.; Souza, M.N.d.; Brindeiro, R.; Queiroz-Telles, F.áv.d. 2010: HIV-1 genotypic resistance profile of patients failing antiretroviral therapy in Paraná, Brazil Brazilian Journal of Infectious Diseases: An Official Publication of the Brazilian Society of Infectious Diseases 14(4): 360-371
Dzangare, J.; Gonese, E.; Mugurungi, O.; Shamu, T.; Apollo, T.; Bennett, D.E.; Kelley, K.F.; Jordan, M.R.; Chakanyuka, C.; Cham, F.; Banda, R.M. 2012: Monitoring of early warning indicators for HIV drug resistance in antiretroviral therapy clinics in Zimbabwe Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 54(Suppl 4): S313-S316
Towler, W.I.; Barlow-Mosha, L.; Church, J.D.; Bagenda, D.; Ajuna, P.; Mubiru, M.; Musoke, P.; Eshleman, S.H. 2010: Analysis of drug resistance in children receiving antiretroviral therapy for treatment of HIV-1 infection in Uganda Aids Research and Human Retroviruses 26(5): 563-568
Di Giambenedetto, S.; Zazzi, M.; Corsi, P.; Gonnelli, A.; Di Pietro, M.; Giacometti, A.; Almi, P.; Trezzi, M.; Boeri, E.; Gianotti, N.; Menzo, S.; Del Gobbo, R.; Francisci, D.; Nerli, A.; Galli, L.; De Luca, A. 2009: Evolution and predictors of HIV type-1 drug resistance in patients failing combination antiretroviral therapy in Italy Antiviral Therapy 14(3): 359-369
Abbas, U.L.; Glaubius, R.; Mubayi, A.; Hood, G.; Mellors, J.W. 2013: Antiretroviral therapy and pre-exposure prophylaxis: combined impact on HIV transmission and drug resistance in South Africa Journal of Infectious Diseases 208(2): 224-234
Zhang, M.; Han, X.-X.; Cui, W.-G.; Jia, M.-H.; Meng, X.-D.; Xing, A.-H.; Wu, Y.-H.; Yang, Y.-Y.; Lu, C.-M.; Hu, Q.-H.; Dai, D.; Zhang, Z.-N.; Shang, H. 2008: The impacts of current antiretroviral therapy regimens on Chinese AIDS patients and their implications for HIV-1 drug resistance mutation Japanese Journal of Infectious Diseases 61(5): 361-365
Kitkungvan, D.; Apisarnthanarak, A.; Laowansiri, P.; Mundy, L.M. 2008: Secure antiretroviral therapy delivery in a resource-limited setting: streamlined to minimize drug resistance and expense HIV Medicine 9(8): 636-641
Baesi, K.; Ravanshad, M.; Ghanbarisafari, M.; Saberfar, E.; Seyedalinaghi, S.; Volk, J.E. 2014: Antiretroviral drug resistance among antiretroviral-naïve and treatment experienced patients infected with HIV in Iran Journal of Medical Virology 86(7): 1093-1098
Puthanakit, T.; Jourdain, G.; Hongsiriwon, S.; Suntarattiwong, P.; Chokephaibulkit, K.; Sirisanthana, V.; Kosalaraksa, P.; Petdachai, W.; Hansudewechakul, R.; Siangphoe, U.; Suwanlerk, T.; Ananworanich, J.; Bunupuradah, T.; Phasomsap, C.; Kaew-on, P.; Kanjanavanit, S.; Hinjiranandana, T.; Layangool, P.; Kamonpakorn, N.; Buranabanjasatean, S.; Ngampiyaskul, C.; Chotpitayasunondh, T.; Chanpradub, S.; Leawsrisuk, P.; Chearskul, S.; Vanprapar, N.; Phongsamart, W.; Lapphra, K.; Chearskul, P.; Wittawatmongkol, O.; Prasitsuebsai, W.; Intalapaporn, K.; Kongstan, N.; Pannin, N.; Maleesatharn, A.; Khumcha, B.; Aurpibul, L.; Wongnum, N.; Nadsasarn, R.; Lumbiganon, P.; Tharnprisan, P.; Udompanich, T.; Yentang, M.; Khonponoi, A.; Maneerat, N.; Denjunta, 2010: HIV-1 drug resistance mutations in children after failure of first-line nonnucleoside reverse transcriptase inhibitor-based antiretroviral therapy HIV Medicine 11(9): 565-572
Ahoua, L.; Guenther, G.; Rouzioux, C.; Pinoges, L.; Anguzu, P.; Taburet, A.-M.; Balkan, S.; Olson, D.M.; Olaro, C.; Pujades-Rodríguez, M. 2011: Immunovirological response to combined antiretroviral therapy and drug resistance patterns in children: 1- and 2-year outcomes in rural Uganda Bmc Pediatrics 11: 67
Corzillius, M.; Mühlberger, N.; Sroczynski, G.; Jaeger, H.; Wasem, J.ür.; Siebert, U. 2004: Cost effectiveness analysis of routine use of genotypic antiretroviral resistance testing after failure of antiretroviral treatment for HIV Antiviral Therapy 9(1): 27-36