Autoimmune peripheral neuropathies with anti-MAG antibodies and hematological disorders. Five cases
Andrès, E.; Vinzio, S.; Maloisel, F.; Carre, S.; Perrin, A.E.; Goichot, B.; Schlienger, J.L.
Annales de Medecine Interne 152(3): 147-151
2001
ISSN/ISBN: 0003-410X PMID: 11431571 Document Number: 527632
The aim of this study was to report our experience with autoimmune neuropathies associated with hematological disorders and to describe their etiological and clinical polymorphism. A retrospective study was conducted in five patients with autoimmune peripheral neuropathies with anti-MAG (myelin-associated glycoprotein) antibodies. Autoimmune neuropathies were associated with Waldenström's macroglobulinemia (n=2), Hodgkin disease (n=1), chronic lymphocytic leukemia (n=1) and idiopathic polyclonal B lymphoproliferation (n=1). Most of the patients had a sensorial polyneuropathy, predominant in the legs, exhibiting slow progress. Our patients showed a disappointing response to chemotherapy with stabilization or short response.