Coexistence of serum anti-DNA topoisomerase I and anti-Sm antibodies: report of 3 cases

Kameda, H.; Kuwana, M.; Hama, N.; Kaburaki, J.; Homma, M.

Journal of Rheumatology 24(2): 400-403

1997


ISSN/ISBN: 0315-162X
PMID: 9035005
Document Number: 480840
We describe 3 Japanese patients having both serum anti-DNA topoisomerase I and anti-Sm antibodies. All 3 patients had typical features of systemic lupus erythematosus, such as glomerulonephritis, in addition to skin thickening and systemic sclerosis related organ involvement, including pulmonary interstitial fibrosis and renal crisis. This is the first report of the coexistence of these 2 disease specific autoantibodies.

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