Estrogen stimulated pathway changes and cold-inactivated enzymes
Peat, R.; Soderwall, A.L.
Physiological Chemistry and Physics 4(3): 295-300
1972
ISSN/ISBN: 0031-9325 PMID: 4376841 Document Number: 5274
It is well established that water near surfaces, including macromolecules and biological material, is very different from bulk water, although the degree of ordering and the distance to which an effect is exerted are still in dispute. Shereshefsky, Bernal, Derjaguin, Drost-Hansen and others have argued for an effect of surfaces on water structure at distances up to hundreds of Angstroms, or even farther. NMR studies have shown that tissue water is more restricted than bulk water, and that the water in young or actively dividing tissue such as cancer (which contains a higher than normal percentage of water) is more "bulk-like" than the water of more mature and stable tissue. Another entropic and energetic interpretation presents dedifferentiation as a simple, stable, and general change of state. Differentiation remains as a highly individualized process, depending on a precise history and environment of each cell. However, the simplicity of this view of dedifferentiation suggests a relatively small number of points at which effective intervention might be made in altering the course of carcinogenesis. It also suggests possible new approaches to fertility, sterility, and aging.
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