Effects of 14-day spaceflight on myosin heavy chain expression in biceps and triceps muscles of the rhesus monkey
Chopard, A.; Leclerc, L.; Pons, F.; Leger, J.J.; Marini, J.F.
Journal of Gravitational Physiology a Journal of the International Society for Gravitational Physiology 7(1): S47-S49
2000
ISSN/ISBN: 1077-9248 PMID: 11543458 Document Number: 525762
In rats, changes in myosin expression are induced by the chronic elimination of weight-bearing activity, particularly in the postural muscles. This occurs during spaceflight and hindlimb suspension. Myosin heavy chain (MHC) changes affect fast and slow fiber types differently depending on muscle function. An increase in co-expression of different MHC within the same fiber will signal early changes in muscle fibers. In the rat soleus muscles, the spaceflight-induced increase in fast MHC expression appears to be essentially due to the enhanced or de novo synthesis of IID or IIX MHC. In response to microgravity, the expression of slow-type myosin decreases, while that of fast-type increases. There is scarce information concerning the effect of microgravity on rhesus monkeys (Macaca mulatta), especially on their upper limbs. We investigated the expression of MHC using an immunocytochemical approach to determine the nature and magnitude of the changes in biceps and triceps muscles of rhesus monkeys during the Bion 11 14-day mission.