Physico-chemical properties and hydrolysis of oxprenolol octanoyl and benzoyl esters
Nogowska, M.
Acta Poloniae Pharmaceutica 57(1): 43-47
2000
ISSN/ISBN: 0001-6837 PMID: 10846796 Document Number: 525496
The kinetics of hydrolysis of octanoyl ester of oxprenolol (O-OXP) and benzoyl ester of oxprenolol (Benz-OXP) has been investigated in aqueous solution at 310 K over the pH range 0.42-9.5. The decomposition was followed by UV spectral method. At the pH range 0.42 to 9.5, hydrolysis of oxprenolol esters (E-OXP) consists of hydrolysis of BH+ molecules catalyzed by hydrogen ions, spontaneous hydrolysis of BH+ molecules and hydrolysis of BH+ and B molecules catalyzed by hydroxide ions. Various buffer substances were found to exhibit general acid and base catalysis of the degradation.