Granulosa cell tumor--clinical group and literature review
Freitag, P.; Janousek, M.; Jancárková, N.; Bendová, M.; Strunová, M.; Zivný, J.
Ceska Gynekologie 65(3): 163-166
2000
ISSN/ISBN: 1210-7832 PMID: 10953492 Document Number: 524835
To present a review of literature and to analyse a clinical retrospective series of patients with granulosa cell tumor. Retrospective study and review. Department of Obstetrics and Gynaecology, First Faculty of Medicine, Prague, Czech Republic. Retrospective analysis of age, stage, surgery, radiotherapy and chemotherapy, survival curve, number of recurrences and time to recurrence. Literature and information database (Medline 1997-1999) review. In a group of 43 patients the median of age was 53.5 years. 83.7% of cases were in a stage I. There were two duplicate tumors in a series. Conservative surgery was performed in 9/43 cases, 5 of them were reoperated on. The most frequent chemotherapy regimens were platinum-cyclophoshamide and BEP (bleomycin, etoposide, platinum). The 5-year overall survival was 86% and specific survival 90.7%. There were 3/43 recurrences, median time to recurrence was 22 months. A good prognosis of a patient with granulosa cell tumor requires a precise histopathologic examination, an adequate surgery and a comprehensive clinical analysis of a case to evaluate an indication of adjuvant therapy. Concentration of patients in oncogynaecological centres is advisable. A careful follow-up because of a risk of late recurrences is necessary.