Exposer rate of hepatitis e (IgG) in a selected population of children and adults in Karachi
Qureshi, H.; Shahid, A.; Mujeeb, S.A.
JPMA. Journal of the Pakistan Medical Association 50(10): 352-354
2000
ISSN/ISBN: 0030-9982 PMID: 11109756 Document Number: 524794
To see exposure rate of hepatitis E (IgG) in 100 apparently healthy children and adults. Sera from 100 healthy children aged 1 day to 10 years and 100 healthy adults aged 18-45 years were analysed for exposure to hepatitis E (IgG) using ELISA. Two samples from children were excluded from the study due to improper storage leaving 98 samples for analysis. Of 98 sera from children 19.4% were positive for IgG indicating previous exposure to hepatitis E. The exposure rate increased with age and was 10% in children below 1 year of age, 14% at 2 years, 19% at 3 years and 28% at 10 years. In adults overall exposure was 16%. There was no predominance of either sex in both the groups and all individuals belonged to middle to lower socioeconomic strata. An exposure of 19% in children and 16% in adults indicates high faecal contamination of drinking water and re-addressing of the issue of use of boiled water on individual level, supply of potable water on the government level and a need to produce a vaccine on international level.