Modifying effect of nitrites on pulmonary blastogenesis and viral leukogenesis in mice: role of nitric oxide and dioxide
Il'nitskiĭ, A.P.; Reutov, V.P.; Ryzhova, N.I.; Kolpakova, A.S.; Deriagina, V.P.; Nekrasova, E.A.; Savluchinskaia, L.A.; Travkin, A.G.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 7: 11-16
2000
ISSN/ISBN: 0869-6047 PMID: 10961141 Document Number: 523614
The long-term effects of sodium nitrite (NaNO2) on carcinogenesis induced by urethane (total dose 1.0 mg/g body weight) in low-grade cancer F1 (C57BLxCBA) and high-grade A/Snell mice and on viral (Rausher leukemia virus) leukomogenesis in Balb/c mice. The murine intake of NaNO2 with water (50 mg/l) causes a statistically significant increase in the number of adenomas in the lung. Examining the mechanism of conversion of NO2- to NO led to the assumption that the free radical compounds NO and NO2 are involved in the potentiating action of NO2 on blastomogenesis. The use of the oxidant emoxypine (3-hydroxypyridine) confirmed the above. The role of NO and NO2 in the intracellular processes under the modifying effects of nitrites and nitrates on blastomogenesis is analyzed.