Free radical concepts in the etiopathogenesis of Graves-Basedow disease
Komosińska-Vassev, K.; Olczyk, K.; Winsz, K.
Postepy Higieny i Medycyny Doswiadczalnej 54(2): 225-237
2000
ISSN/ISBN: 0032-5449 PMID: 10857382 Document Number: 523335
Increased metabolism due to hyperthyroidism leads to the dysfunction of the mitochondria respiratory chain, resulting in elevated formation of the reactive oxygen species in the course of Graves-Basedow disease. It has also been reported that excessive thyroid hormone level may induce oxidative tissue injury. Furthermore, Graves-Basedow disease is frequently associated with changes of the antioxidant defence system activity. The disturbed balance between oxidative and antioxidative processes may be of significant importance in the pathogenesis of Graves-Basedow disease.