Cerebriform plantar hyperplasia: ultrastructural study of two cases
Winik, B.C.; Boente, M.C.; Asial, R.A.
European Journal of Dermatology Ejd 10(7): 551-554
2000
ISSN/ISBN: 1167-1122 PMID: 11056430 Document Number: 523009
In the present work we report the histopathological features of the cerebriform plantar hyperplasia observed in two patients with a mild form of the Proteus syndrome. Light microscopy revealed increased fibro-adipose tissue and adnexal structures in the dermis. Ultrastructurally, densely packed collagen fibrils variable in diameter and configuration, described as composite fibrils and unraveled fibrils, as well as a few fragmented elastic fibrils presenting an altered ratio between the elastin and the microfibrillar components were the major features observed. We consider that these histopathological findings will contribute to further delineate cerebriform plantar hyperplasia and also to establish clues for the early diagnosis of the Proteus syndrome.