Analysis of HLA class i and Ii antigens composition in high-risk pregnancy
Mikłaszewicz, A.; Szmigiel-Sipak, O.; Ronin-Walknowska, E.; Hałasa, J.; Giedrys-Kalemba, S.
Ginekologia Polska 71(6): 491-499
2000
ISSN/ISBN: 0017-0011 PMID: 11002551 Document Number: 522646
We have analyzed the frequency of HLA class I and II antigens in high-risk pregnancy. Altogether, 22 gravida hospitalized at the Department of Pathology of Pregnancy and Labour, Pomeranian Medical University in Szczecin formed group I (PE) with 12 cases of preeclampsia and group II with 10 cases of the antiphospholipid syndrome (APS). The control group included 40 multigravida. Typing of HLA class I and II antigens was done using the two-stage microcytotoxic test (NIH) of Mittal. Antigen B35 was found more frequent in preeclampsia and antiphospholipid syndrome groups than in multigravida. Furthermore, a statistically significant difference in the frequency of homozygotes for the HLA-DR locus was noted between groups PE and APS on one hand, and controls on the other. Identical HLA-DR3, DR4 and DR5 antigens were found more frequently in preeclampsia, while identical DR4 and DR6 in the antiphospholipid syndrome.