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Cytokines in the treatment of a generalized surgical infection

Pal'tsev, A.V.; Ovechkin, A.V.; Zakharova, N.F.; Rovina, A.K.; Leplina, O.Iu.; Shevela, E.Ia.; Ostanin, A.A.; Chernykh, E.R.

Anesteziologiia i Reanimatologiia 2000(2): 27-30

2000

ISSN/ISBN: 0201-7563
PMID: 10833832
Document Number: 522568
A novel approach to the treatment of surgical sepsis has been tried: cytokine-based immunotherapy. Human recombinant interleukin-2 (IL-2) and a mixture of native cytokines obtained by arteriovenous perfusion of xenospleen were used as a source of proinflammatory cytokines. Extracorporeal immunotherapy of 62 patients with surgical sepsis with mononuclear cells treated by autologous IL-2 resulted in a significant decrease of endotoxicosis and effective immuno-correction. Cytokine-based immunotherapy notably decreased the mortality of patients with generalized surgical infection - to 14.6%, which was lower than the expected mortality (35%) and the mortality in the control group (34.5%).

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