The chemotherapeutic efficacy of ciprofloxacin and lomefloxacin in the inhalation method of infecting white mice with tularemia
D'iakov, S.I.; Bubnov, V.P.; Lebedeva, I.K.; Sidorenko, S.V.; Moskalenko, V.I.
Antibiotiki i Khimioterapiia 45(6): 17-20
2000
ISSN/ISBN: 0235-2990 PMID: 10904804 Document Number: 522334
Peculiarities of the protective effect of ciprofloxacin and lomefloxacin were studied and the optimal regimens of their use were determined in multifactor experiments on albino mice infected with finally dispersed aerosol of the virulent strain of the European subspecies of Francisella tularensis. As for protective effect, the fluoroquinolones provided high percentage of the animal survival. The optimal course of the treatment was at least 7 days. The interval of 0 to 48 hours between the infection and the start of the treatment had no statistically significant effect on chemotherapeutic efficacy of fluoroquinolones.