Squamous intraepithelial lesions (SILs) and HPV associated changes in HIV infected women or at risk of HIV. DIANAIDS Cooperative Study Group
Branca, M.; Migliore, G.; Giuliani MLeoncini, L.; Ippolito, G.; Cappiello, G.; Garbuglia, A.R.; Schiesari, A.; Rezza, G.
European Journal of Gynaecological Oncology 21(2): 155-159
2000
ISSN/ISBN: 0392-2936 PMID: 10843475 Document Number: 521554
The study concerns the prevalence of squamous intraepithelial lesions (SILs) and the specific cervical cytopathological features of a group of HIV-positive and a group of HIV-negative women recruited in a multicentric cohort study. The assessment of HPV-DNA genotypes was carried out in both groups. 459 women, 266 HIV-positive and 193 HIV-negative women at risk were examined in an Italian multi-institutional study involving 14 gynaecological centres. In our samples, the risk of SILs was 29.4% for HIV-positive women and 10% for HIV-negative women (O.R. = 3.90, C.I. 95%: 2.20-6.98) while HPV-DNA-PCR genotypes had a high prevalence in both groups of HIV-positive and HIV-negative women. Cytopathological features of SILs in HIV-positive women were: a higher number of koilocytes and a more marked atypia of high grade neoplastic cells. A higher prevalence of SILs as well as a specific cervical cytopathology might suggest HIV infection.