The structural organization of the normal rat area postrema and under conditions of chronic exposure to gravitational loads
Pashchenko, P.S.; Sukhoterin, A.F.
Morfologiia 117(2): 36-41
2000
ISSN/ISBN: 1026-3543 PMID: 10853249 Document Number: 520970
Topography and structure of rat area postrema were specified using light optic and electron microscope. Disturbance of liquor-encephalic transport (hydrops of ependymocytes), sharp changes of cytoplasmic organelles in neurons, signs of intercellular desintergration (synapse degeneration after "clear" type), death of part of neurons, disorder in secretory processes in neuroendocrine cells were shown to occur following chronic effect of gravitation overloads, in its structural elements. These changes take place on the background of hemomicrocirculatory disturbances, appearance of connective tissue fibres in perivascular space of Virchow-Robin and are probably conditioned by a developing circulatory hypoxia.