Recurrent Clostridium difficile enterocolitis
Bergamin, B.; Hess, T.; Jost, R.; Ballmer, P.E.; Imoberdorf, R.
Schweizerische Medizinische Wochenschrift 130(44): 1681-1684
2000
ISSN/ISBN: 0036-7672 PMID: 11103440 Document Number: 520489
Pseudomembranous enterocolitis generally occurs after antibiotic treatment. The standard treatment is oral metronidazol or vancomycin. Nevertheless, relapses of Clostridium difficile enterocolitis are observed in 10-25% of cases. Factors associated with recurrences include endogenous reinfection by spore formation, selective IgG1 or IgA deficiency or infection with mutated strains of Clostridium difficile. Recurrent Clostridium difficile enterocolitis may be treated with repeat oral vancomycin combined with Sacchoromyces boulardii, with intravenous immunoglobulin for severe colitis.