Virilizing granulosa cell tumor responsive to human chorionic gonadotropin and oral contraceptive with 8-year followup
Zaydon, C.; Bogaars, H.A.; Tucci, J.R.
International Journal of Gynaecology and Obstetrics the Official Organ of the International Federation of Gynaecology and Obstetrics 29(1): 87-90
1989
ISSN/ISBN: 0020-7292 PMID: 2566535 DOI: 10.1016/0020-7292(89)90135-5Document Number: 520394
Urinary and serum steroid measurements were obtained in a 48-year-old female before and after the removal of a virilizing granulosa cell tumor (GCT). Preoperatively, serum testosterone was markedly elevated while 17-ketosteroid (17-KS) and estrogen excretion were normal. Chorionic gonadotropin administration effected a marked rise in urinary 17-KS excretion and serum testosterone while oral contraceptive therapy for 21 days decreased serum testosterone to normal. With tumor resection, serum testosterone fell to normal and subsequent administration of HCG had no stimulatory effect on serum testosterone or urinary 17-KS excretion. The patient's clinical response and 8-year followup attest to the tumor's unusual virilizing role.