Nociceptive system response to repetitive painful stimuli during chronic psychoemotional stress in humans
Ashkinazi, I.I.; Vershinina, E.A.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 86(11): 1441-1448
2000
ISSN/ISBN: 0869-8139 PMID: 11195211 Document Number: 519823
Repeated nocigenic stimuli applied to the skin evoked a hyperalgesia in healthy subjects while in patients with neurasthenia which is a natural model of a chronic psychoemotional stress, they evoked a hyperalgesia accompanied by sensitization. The differences in the nociceptive system responses show particularities in reactivity (plasticity) of a wide dynamic range of the spinal neurons under chronic psychoemotional stress that is due to disorders in supraspinal descending modulation system of plasticity in the spinal nociceptive neurons.