Effect of macarbomycin on transfer of R factor among strains of Escherichia coli in vitro
Fukuyasu, T.; Shimizu, T.; Terakado, N.
National Institute of Animal Health Quarterly 12(4): 201-206
1972
ISSN/ISBN: 0027-951X PMID: 4574595 Document Number: 51954
Macarbomycin, a new antibiotic developed as a food additive, showed much greater antibacterial activity against procine E. coli strains carrying a transferable drug-resistance factor (R factor) than against a strain in which the R factor had been eliminated by the penicillin screening method. An E. coli strain with the fertility inhibition (Ffi+) R factor was more sensitive to macarbomycin than a strain with the 'fi' R factor. Macarbomycin decreased the R factor transfer frequency.