Cell transplantation in hepatology
Von Weizsäcker, F.
Praxis 89(43): 1749-1752
2000
ISSN/ISBN: 1661-8157 PMID: 11103620 Document Number: 519333
Preclinical studies have shown that hepatocytes transplanted into the liver function normally on a long term basis. The procedure is well tolerated and offers a wide range of potential clinical applications. Clinical case studies have been performed in the setting of acute and chronic liver failure as well as metabolic diseases. In particular, the case of a patient with Crigler-Najjar Syndrome Type I clearly demonstrated the long term viability of transplanted hepatocytes with stable metabolic function. Further studies are warranted to assess the full therapeutic potential of hepatocyte transplantation.
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