The antimicrobial activity and acute toxicity of the polymer salts of gentamycin
Solovskiĭ, M.V.; Zaikina, N.A.; Okulova, N.V.; Belokhvostova, A.T.
Antibiotiki i Khimioterapiia 45(6): 10-12
2000
ISSN/ISBN: 0235-2990 PMID: 10904802 Document Number: 518820
By neutralization of copolymers of N-(2-hydroxypropyl) methacrylamide with acrylic acid and copolymers of N-vinylpyrrolidone with crotonic and p-crotonoylaminophenoxyacetic acids in the presence of gentamycin, water-soluble polymer salts containing from 10 to 25 mass% of gentamycin were obtained. These salts regardless of gentamycin content completely retain high level of antimicrobial activity of gentamycin against Staphylococcus spp. and Escherichia coli and are characterized by less (by more than one order of magnitude) acute toxicity.