The MDR gene and cellular sensitivity to various effects
Zubova, S.G.; Danilov, A.O.; Myshkov, A.I.; Bykova, T.V.; Zaritskiĭ, A.I.; Okulov, V.B.
Voprosy Onkologii 46(2): 199-201
2000
ISSN/ISBN: 0507-3758 PMID: 10853421 Document Number: 518024
Mdr-Transfected K-562 cells revealed a relatively high resistance to cytotoxic monokines and ionizing radiation as compared to parental cells. Taken together with what is known about the resistance of mdr-expressing cells to multiple cytotoxic drugs, our results point to malignant cells having universal mechanisms of chemo-, bio- and radioresistance.
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