Brain ischemia induced by gravitational overload
Gaevyĭ, M.D.; Adzhienko, L.M.; Makarova, L.M.; Abdulsalam, A.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 63(3): 63-64
2000
ISSN/ISBN: 0869-2092 PMID: 10934600 Document Number: 517627
It is suggested that radial gravitational overloads in craniocaudal direction, during which the pressure in meningeal arteries drops to zero, can be used to model the ischemic state. The post-ischemic period is characterized by increasing content of lipid peroxidation products in the venous blood and by violation of the neurological state in rats. This ischemia model, requiring no anaesthesia for the experimental animals, can be used in the directed search for new neuroprotectors and their characterization.