Diovan effectiveness in combined treatment of severe arterial hypertension
Bichan, N.A.; Maslov, A.P.
Terapevticheskii Arkhiv 72(8): 34-36
2000
ISSN/ISBN: 0040-3660 PMID: 11019424 Document Number: 516695
Aim: To assess effectiveness of diovan, a novel angiotensin-II antagonist, in combined hypotensive treatment of patients with severe arterial hypertension. Material and methods: 15 patients with severe arterial hypertension received diovan in a dose 80-160 mg/day for 8 weeks in combination with clofelin, beta-adrenoblockers, ACE inhibitors, diuretics prescribed before the start of diovan. Diovan effects were studied by 24-h monitoring of arterial pressure, tolerance, changes in blood counts, central hemodynamics. Results. Adjuvant hypotensive treatment with diovan lowered arterial pressure to satisfactory levels in 80% of patients. 13.3% did not respond to diovan. 6.7% of patients were withdrawn because of allergy. Only 2 patients of those who completed the diovan course developed side effects in first two weeks of the treatment - they had head ache. Conclusion: Diovan is effective in combination with clofelin, ACE inhibitors, diuretics, beta-adrenoblockers.