Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis
Mori, H.; Kawabata, K.; Matsunaga, K.; Ushida, J.; Fujii, K.; Hara, A.; Tanaka, T.; Murai, H.
Biofactors 12(1-4): 101-105
2000
ISSN/ISBN: 0951-6433 PMID: 11216469 Document Number: 516098
Polyphenolic compound chlorogenic acid (CGA) known to be much contained in coffee beans was found to have a regressive effect on induced aberrant crypt foci (ACF) as well as on development of ACF in azoxymethane (AOM)-induced colorectal carcinogenesis in rats. Rice germ and gamma-aminobutyric acid-enriched defatted rice germ inhibited AOM-induced ACF formation and colorectal carcinogenesis in rats. Ferulic acid (FA) also known to be contained in coffee beans and rice prevented AOM-induced ACF formation and intestinal carcinogenesis in rats. Both of food factors, coffee and rice may be of benefit to prevention of human colorectal cancers.