Evaluation of chemopreventive effects of betel leaf on the genotoxicity of pan masala
Trivedi, A.H.; Patel, R.K.; Rawal, U.M.; Adhvaryu, S.G.; Balar, D.B.
Neoplasma 41(3): 177-181
1994
ISSN/ISBN: 0028-2685 PMID: 7935987 Document Number: 431103
In India, pan masala and tobacco. The effects of 3 aqueous extracts (P. betle leaves, and pan masala with or without tobacco) on chromosome aberrations (CA) and sister chromatid exchange (SCE) in Chinese hamster ovary cells were studied. The P. betle extract (15 micro l/ml) significantly increased the incidence of CA (from 28 to 56) and SCE (from 676 to 776). Short-term treatment of the cells with a combination of pan masala extracts + P. betle extract had no effect on the incidence of CA and SCE. Long-term treatment with pan masala (5 micro l/ml) + P. betle (10 or 15 micro l/ml) extracts or pan masala with tobacco (5 micro l/ml) + P. betle (10 or 15 micro l/ml) extracts significantly decreased the incidence of CA and SCE when compared with those observed with pan masala treatments alone.