Prolonged desensitization pretreatment for in vitro fertilization in women with polycystic ovary
Kuczyński, W.; Czech, R.; Redźko, S.; Wasilewski, T.; Mrugacz, G.; Wołczyński, S.; Pietrewicz, P.; Grochowski, D.; Szamatowicz, M.
Ginekologia Polska 71(9): 1059-1063
2000
ISSN/ISBN: 0017-0011 PMID: 11082975 Document Number: 515946
To analyse the outcome of intracytoplasmic sperm injection (ICSI) in women with severe polycystic ovary disease (PCD), stimulated after prolonged pituitary desensitization in comparison with regular long protocol therapy. The results of controlled ovarian hyperstimulation (COH), fertilization rate, early embryo development parameters and clinical pregnancy rates were compared depending on the duration of pituitary desensitization before gonadotropin administration. A total of 60 patients with severe PCOD were desensitized with GnRH agonist up to 30 days before COH. The results were compared with the group of 213 patients with mild PCOD treated with regular long protocol (control). We observed a slightly higher rate of mature oocytes MII as well as the number of embryos obtained in the control group, however the pregnancy rate in the group with prolonged desensitization was significantly higher (50%) in comparison to the control group (33.8%). The prolonged pituitary desensitization before controlled ovarian hyperstimulation gives better chance for obtaining pregnancy in patients with severe PCOD. It could be recommended facing previous treatment failure.