Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome
Hwu, Y.M.; Lin, S.Y.; Huang, W.Y.; Lin, M.H.; Lee, R.K.K.
International Journal of Gynaecology and Obstetrics the Official Organ of the International Federation of Gynaecology and Obstetrics 90(1): 39-43
2005
ISSN/ISBN: 0020-7292 PMID: 15921686 DOI: 10.1016/j.ijgo.2005.04.004Document Number: 254807
To evaluate the effect of ultra-short (12 days) metformin pretreatment in clomiphene-citrate (CC) resistant polycystic ovary syndrome (PCOS). Eighty women with CC-resistant PCOS were randomly allocated to metformin pretreatment or usual treatment. Forty women received 1500 mg metformin daily for 12 days, followed by clomiphene 150 mg daily for 5 days along with metformin. Forty women (control group) received the same dose of clomiphene but no metformin pretreatment. In the metformin group, 17 (42.5%) women ovulated, and 6 (15%) conceived. In the control group, 5 (12.5%) women ovulated but none conceived. Compared with the control group, the metformin group had significantly higher ovulation (P = 0.03) and pregnancy rates (P = 0.026). Twelve days of metformin pretreatment improves ovulation and pregnancy rates in women with CC-resistant PCOS.
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