Lipid and lipoprotein patterns in type 2 non-obese diabetic patients. Do Lp (a) levels decrease with improved glycemic control in these patients?
Alagözlü, H.; Gültekin, F.; Candan, F.
Nutrition Metabolism and Cardiovascular Diseases Nmcd 10(4): 204-208
2000
ISSN/ISBN: 0939-4753 PMID: 11079258 Document Number: 515394
In this study, we investigated the levels of apolipoprotein-AI (apo-AI), apolipoprotein (apo-B), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), total cholesterol and lipoprotein(a) in a group of non-obese, type 2 diabetes mellitus patients with different types of treatment and in a control group of non-obese, non-diabetic subjects [Turkey]. Patients were divided into 3 groups according to their treatment types: insulin, sulfonylurea and untreated groups. All groups were similar in sex, weight, known duration of diabetes and habits. Each group consisted of 30 subjects. There were no differences in apo-AI, apo-B and TG levels (P>0.05), whereas HDL-C levels in the untreated group were significantly lower than those of the other groups (P<0.05). Lp(a) levels in the untreated group were higher than in the other (P<0.05). It is concluded that gaining metabolic control in diabetes mellitus is crucial in pulling back lipid, lipoprotein and apolipoprotein levels to a desired level and in attenuating CAD (coronary artery disease) risk factors, and also in preventing CAD. Lp(a) levels in particular are decreased by insulin or sulfonylurea in non-obese patients with type 2 diabetes mellitus.