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Insulators and interaction between long-distance regulatory elements in higher eukaryotes

Georgiev, P.G.; Murav'eva, E.E.; Golovnin, A.K.; Gracheva, E.M.; Belen'kaia, T.I.

Genetika 36(12): 1588-1597

2000

ISSN/ISBN: 0016-6758
PMID: 11190466
Document Number: 514958
Enhancers can activate a promoter located as far as several hundred kilobases away, which is specific for transcription regulation in higher eukaryotes. Notwithstanding the vast information accumulated on transcription regulation at various levels, the mechanism of long-distance enhancer-promoter interactions is still obscure. Modern views of insulators as elements modulating enhancer-promoter interactions are reviewed.

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