Clinical trials results of a unique monoclonal antibody in asthma
Berger, W.E.
Allergie et Immunologie 32(9): 333-335
2000
ISSN/ISBN: 0397-9148 PMID: 11195855 Document Number: 514933
IgE binds to high affinity receptors (Fc epsilon RI) on mast cells, basophils, alveolar macrophages, and antigen-presenting cells. This results in the degranulation of effector cells and the release of mediators, such as histamine, leukotrienes, cytokines, that are causally linked to the pathophysiology of allergic asthma. It made for an attractive target for the development of a unique humanized monoclonal antibody, rhuMAb-E25 (E25). E25 offers a novel strategic approach to allergy treatment, it is expected that using E25 to significantly decrease IgE levels will result in improved control of allergic asthma.