The effects of intravenous milrinone for the patient undergoing CABG
Yasuda, F.; Shimono, T.; Cruz, B.P.; Komada, T.; Tokui, T.; Onoda, K.; Tanaka, K.; Shimpo, H.; Yada, I.; Okuda, M.; Utsunomiya, H.; Maruyama, K.
Kyobu Geka. Japanese Journal of Thoracic Surgery 53(2): 117-121
2000
ISSN/ISBN: 0021-5252 PMID: 10667021 Document Number: 514172
The hemodynamic effects of intravenous infusion of milrinone were evaluated in 25 patients undergoing CABG using an internal mammary artery graft. Milrinone was administered to 9 patients at the time of weaning from cardiopulmonary bypass, at a dosage of 3 to 5 micrograms/kg/min. Postoperative cardiac function was compared in this group versus the other 17 patients who were treated without milrinone. We determined such parameters as cardiac index, wedge pressure and mean pulmonary pressure. Our findings did not show any significant difference between the 2 groups. We also studied a subject of low-output patients (EF < 0.5). In the patients with low-cardiac output, the use of milrinone in addition to standard postoperative administration of low-dose dopamine reduced mean pulmonary pressure and wedge pressure. Thus, milrinone not only improved the left ventricular function, but also expanded the pulmonary vascular bed.