A case of acute recurrent benign pericarditis in a patient with glucose-6-phosphate dehydrogenase deficiency, treated with sodium salicylate
Tedeschini, R.C.; Ruggiano, G.; Sofo, D.; Poggesi, L.
Annali Italiani di Medicina Interna Organo Ufficiale Della Societa Italiana di Medicina Interna 15(2): 166-168
2000
ISSN/ISBN: 0393-9340 PMID: 10920507 Document Number: 514020
Glucose 6-phosphate dehydrogenase deficiency is an important cause of hemolysis. People with this disease are prone to hemolytic crisis induced by drugs, including acetylsalicylic acid. Sodium salicylate is the main therapeutic choice for acute idiopathic pericarditis. In vitro studies have demonstrated the role played by sodium salicylate in the inhibition of glucose 6-phosphate dehydrogenase, but, at therapeutic doses, this inhibition is not enough to explain acetylsalicylic acid-induced hemolysis observed in vivo. We thus treated a patient affected by acute idiopathic pericarditis and glucose 6-phosphate dehydrogenase deficiency with sodium salicylate, obtaining complete resolution of fever and symptoms, without any hemolytic complication. Therapy with sodium salicylate could thus be a safe and effective alternative for patients with glucose 6-phosphate dehydrogenase who require anti-inflammatory therapy.
Document emailed within 1 workday
