A case of acute urticaria from hydroxyzine hydrochloride used for preanesthetic medication
Urabe, K.; Fujii, K.; Tezuka, M.; Okuda, Y.; Kitajima, T.; Yamazaki, T.; Yamakage, A.
Masui. Japanese Journal of Anesthesiology 49(8): 890-892
2000
ISSN/ISBN: 0021-4892 PMID: 10998884 Document Number: 513866
We report a case of acute urticaria probably caused by hydroxyzine hydrochloride. A 66-year-old male was scheduled for cardiac cystectomy by thoracic endoscopy. The patient was premedicated with atropine and hydroxyzine intramuscularly 30 min before arrival in the operating room. Abrupt general exanthema was observed when intravenous infusion was started. Although his general condition was stable, the operation was postponed. Three days later, the skin test was performed using several drugs. Only hydroxyzine hydrochloride gave positive result. It is assumed that hydroxyzine hydrochloride may have caused his urticaria.