Biochemical studies of a natural antioxidant isolated from rosemary and its application in cosmetic dermatology
Calabrese, V.; Scapagnini, G.; Catalano, C.; Dinotta, F.; Geraci, D.; Morganti, P.
International Journal of Tissue Reactions 22(1): 5-13
2000
ISSN/ISBN: 0250-0868 PMID: 10937349 Document Number: 513864
Skin, which has a highly differentiated and complex structure, is particularly vulnerable to free radical damage because of its contact with oxygen and with other environmental stimuli. The purpose of this study was to investigate the effectiveness of a natural extract derived from rosemary to protect against free radical-induced skin damage in man. We provide evidence that an alcoholic extract of rosemary leaves, Rosm1, is endowed with strong antioxidant activity and, as evaluated by both in vitro and in vivo systems, is capable of inhibiting oxidative alterations to skin surface lipids. The present study provides a preclinical perspective on the interface between the biochemical properties of a natural extract isolated from rosemary leaves, a better understanding of the endogenous antioxidant potential of skin and the real validity of natural antioxidant biotechnology in antiaging skin management.