Introduction of a benzoyl group onto 6-chloropurine riboside in aqueous solution and its application to the synthesis of nucleoside derivatives
Maruyama, T.; Kozai, S.; Takamatsu, S.; Izawa, K.
Nucleic acids symposium series 2000(44): 103-104
2000
ISSN/ISBN: 0261-3166 PMID: 12903289 Document Number: 513288
A benzoyl group was introduced onto the 3'-hydroxyl group of 6-chloropurine riboside by treatment with benzoic anhydride in the presence of a base in aqueous solution. The product (3b) was converted to 9-(2,3-Di-deoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine (1, FddA) in 6 steps, including radical deoxygenation.
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