Metabolic effects of quinapril in hepertensive patients
Zonis, B.Ia.; Volkova, N.I.; Martirosov, V.Iu.; Kharakhashian, A.V.
Terapevticheskii Arkhiv 72(1): 45-47
2000
ISSN/ISBN: 0040-3660 PMID: 10687206 Document Number: 513148
Aim: The study of antihypertensive and metabolic effects of quinapril (accupro) in patients with essential hypertension (EH). Materials and methods: Serum levels of cholesterol, its fractions and triglycerides were measured and standard glucose tolerance test was made in 40 EH patients before accupro therapy and 1 and 3 months after continuous accupro treatment (10-20 mg/day). Results: Antihypertensive effect of accupro was accompanied by marked improvement in carbohydrate and lipid metabolism in 28 patients. Normalization of blood pressure in the absence of negative effect of accupro on parameters of carbohydrate and lipid metabolism was recorded in 12 patients free of co-existing metabolic disorders. Conclusion: The results of the trial allow to recommend antihypertensive treatment with accupro as effective both in patients with metabolic disorders and free of them.