Metabolic effects of berlipril-5 in patients with non-insulin dependent diabetes mellitus and arterial hypertension
Ametov, A.S.; Gubina, E.V.
Terapevticheskii Arkhiv 71(10): 22-25
1999
ISSN/ISBN: 0040-3660 PMID: 10612168 Document Number: 510281
Aim. To study metabolic effects of berlipril-5 (enalapril) in patients with non-insulin-dependent diabetes mellitus (NIDDM) and arterial hypertension (AH). Materials and methods. 24 patients with NIDDM and AH were divided into three groups by the level of basal C-peptide: > 2 ng/ml (group 1), 2-4 ng/ml (group 2) and < 4 ng/ml (group 3). Results. A correlation was found between the level of basal C-peptide and duration of AH (r = 0. 7) and NIDDM (r = -0.47), between the level of triglycerides (TG) and glycolized hemoglobin Hb AIc (r = 0.48). Berlipril treatment reduced basal C-peptide level in groups 2 and 3 by 20.65 +- 1.95% and elevated it in group 1 by 16.4+1.5%. Fasting glucose levels lowered by 9.2 +- 1.95% indicating better sensitivity of the liver to insulin. Blood glucose levels 2 hours after meal fell by 8.3 +- 0.95% (p < 0.05) and Hb AIc by 8.14 +- 1.25% showing indirectly diminishing insulin-resistance at the level of peripheral tissues. TG and VLDLP significantly declined. Conclusion. Inhibitors of angiotensin converting enzyme (enalapril, in particular) produce a positive effect on carbohydrate and lipid metabolism in patients with NIDDM and AH.