Genome analysis of pathogenic bacteria--a review
Nakazawa, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 58(6): 1315-1325
2000
ISSN/ISBN: 0047-1852 PMID: 10879059 Document Number: 513086
The whole genome information on pathogenic bacteria opened a new era of medical microbiology. Bacteria have a variety of strategies to survive in human body against host defense. Bacteria colonizing on the mucous cell surface and proliferate extracellularly have developed a number of paralogs of surface proteins for antigenic variation, while bacteria which proliferate intracellularly have acquired genes for invasion and anti-active oxygen. The obligate intracellular parasites, Rickettsiae and Chlamydiae, have developed a distinct energy metabolism depending on the intracellular localization; Rickettsia prowazekii has TCA cycle and oxidative phosphorylation to proliferate in the cytoplasm, while Chlamydiae have a glycolytic pathway and substrate-level phosphorylation to multiply within an organella called inclusion bodies.