A problem on the pathogenic role of Citrobacter of enteric bacteria
Sakazaki, R.; Namioka, S.; Osada, A.; Yamada, C.
Japanese Journal of Experimental Medicine 30: 13-21
1960
ISSN/ISBN: 0021-5031 PMID: 14440860 Document Number: 2759
With a new planting agar medium, DHL agar, Citrobacter was detected in normal and pathological materials from man and animals. As a result, it was isolated from about 60% and was found in pure culture in 3.4% of the normal feces. It resided in some persons for 4 months similar to Escherichia. It increased in the intestinal tract not only in diarrhea but in hepatitis, icterus, and enterostenosis. Agglutinins corresponding to Citrobacter antigens were demonstrated, with high titer, in serum which had not been related to diarrhea. From these results, the authors consider that Citrobacter organisms are normal inhabitants in the intestinal tract and their abundant appearance in the tract often arises as the results of diarrhea or by any other unknown cause. Serologic examination was carried out on 669 Citrobacter cultures isolated from various materials. The results indicated that no particular Ogroup or type was related to diarrhea, except a few cultures possessing Salmonella O antigens which were found only in pathological materials as possible pathogens. Under these circumstances, it would be premature to incriminate common Citrobacter types as causative agents of intestinal infection, even if they were found in the infection in any conditions. Of the Citrobacter cultures isolated as mentioned aove, about 65% were typable with antiserums of the Bethesda-Ballerup group established by West and Edwards, but the remaining 35% were not. Further serological typing of the organisms needs more studies on the basis of the Bethesda-Ballerup group.
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