PPARs, cancer cells and inflammation
Tomita, K.; Hanafusa, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 58(2): 461-464
2000
ISSN/ISBN: 0047-1852 PMID: 10707577 Document Number: 512991
The peroxisome proliferator-activated receptor-gamma (PPAR gamma) is a ligand-dependent nuclear receptor that has been implicated in the modulation of aspects of development and homeostasis, including adipocyte differentiation and glucose metabolism. Recent reports indicate that PPAR gamma is also expressed at significant level in several other tissues, including macrophages, monocytes and aortic smooth muscle and cancer cells. In this point of view, PPARs are susceptible to mediated the modulation of immune cell activation and tumor cell differentiation. If a major role for PPARs in tumor cell differentiation is manifested, PPARs may also provide a link between nutrition and certain types of cancers.