Multiple myeloma showing increased accumulation of Tc-99m hexamethylpropylene amine oxime on brain SPECT
Takeshita, T.; Kaminaga, T.; Kikuchi, Y.; Furui, S.
Clinical Nuclear Medicine 25(6): 495-496
2000
ISSN/ISBN: 0363-9762 PMID: 10836712 Document Number: 512871
The authors report a case of multiple myeloma with increased accumulation of Tc-99m hexamethylpropylene amine oxime (HMPAO) on brain SPECT. Tc-99m HMPAO is a lipophilic compound that freely passes through the intact blood-brain barrier and cell membrane and is rapidly converted to a hydrophilic form by glutathione and then retained in the neuron for several hours. In general, Tc-99m HMPAO shows decreased accumulation in brain tumors. However, some reports of increased accumulation in brain tumors, such as meningioma, glioblastoma multiforme, high-grade astrocytoma, pituitary adenoma, and multiple myeloma, have been published. The Tc-99m HMPAO uptake in these tumors has been attributed to tumor blood flow or glutathione contents within the tumor. With regard to uptake to Tc-99m HMPAO in multiple myeloma, the tumor size is considered to be an additional factor.