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Genotype-specific changes of certain functional indicators of immunocompetent cells in male laboratory mice under conditions of pheromone stress

Daev, E.V.; Vorob'ev, K.V.; Shustova, T.I.; Zimina, S.A.; Samotokin, M.B.

Genetika 36(8): 1055-1060

2000

ISSN/ISBN: 0016-6758
PMID: 11033776
Document Number: 512744
Mature laboratory male mice CBA, C57BL/6, BALB/c, and hybrids CBAB6F1 were exposed for 2 or 24 h to vapors of 2,5-dimethylpyrazine (DMP), which is a pheromone of the house mouse. This caused changes in the content of noradrenaline within the nerve fibers of both nasal mucosa and vascular testis tunic and an inhibition of leukocyte migration in the peripheral blood. Intrastrain distinctions were also revealed in the level of spontaneous leukocyte migration and intensity of the response to the DMP. The mechanisms underlying these effects and their possible adaptive significance are discussed.

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