Mammary carcinogenesis in female and male mice receiving contraceptives or gestagens

Rudali, G.; Coezy, E.; Chemama, R.

Journal of the National Cancer Institute 49(3): 813-819

1972


ISSN/ISBN: 0027-8874
PMID: 4119120
Document Number: 51257
None of the oestrogen-progestin mixtures Enovid, Ovulen and Lutestral (at 8 mg/kg diet) or their gestagens, despite their oestrogen content, accelerated or raised the frequency of mammary carcinogenesis in C3H, R111 and (C3H X R111)F, intact female mice. Norethynodrel (at 13.5 mg/kg diet) and chlormadinone acetate (at 8 mg/kg diet) delayed appearance of tumours. Effects upon mammary glands of male mice are also described.

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