Spectroscopic characterization of chemokines: relevance for quality control and standardization
Rajarathnam, K.; Crump, M.P.; Clark-Lewis, I.; Sykes, B.D.
Developments in Biological Standardization 97: 49-57
1999
ISSN/ISBN: 0301-5149 PMID: 10463530 Document Number: 511787
Chemokines are mediators of inflammation and trafficking of cells of the immune system including a pivotal role in the recruitment and activation of leukocytes. Due to their involvement in a variety of disease processes, chemokines are potential therapeutic targets. The use of chemokines as pharmaceuticals will require that the folded state and the association properties of the protein are well characterized. In this report, we describe the utility of nuclear magnetic resonance spectroscopy as a tool to study these aspects of chemokine structural properties.