Comparative study of a new beta-adrenergic stimulant in asthma: salbutamol
Gayrard, P.; Orehek, J.; Charpin, J.
Postgraduate Medical Journal 47 Suppl: 46-50
1971
ISSN/ISBN: 0032-5473 PMID: 4396720 Document Number: 5115
An adrenergic stimulant such as salbutamol is effective in spontaneous as well as induced airway obstruction (allergic and non-specific). Most of the effect appears within the first minute after inhalation, the same as after other p-stimulants. The maximal effect is noted at the tenth minute, similar to what Aepli (1967) found with isoprenaline and orciprenaline, different from Warrell et al (1970), namely 60 minutes. There is a great variation in the response to ß-stimulation between patients. The immediate effectiveness of bronchodilator agents depended on the degree of airway obstruction present before it is administered, as shown already by Hume and Jones (1960). Aepli (1967) gave a different interpretation. This assumption is indeed wrong as far as longterm effectiveness is concerned. Since Ra after salbutamol usually remained at values higher than normal, it can be concluded that in those cases ß blockade constituted only part of the airway obstruction.
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