Tremor measurement in asthma. II. Changes after terbutaline administration suggesting beta-adrenergic blockade
van den Berg, W.; Fokkens, J.; Leferink, J.G.; Kreukniet, J.; Maes, R.A.; Bruynzeel, P.L.
European Journal of Respiratory Diseases 63(5): 392-398
1982
ISSN/ISBN: 0106-4339 PMID: 6291971 Document Number: 185639
Repeated finger tremor measurements were performed in 6 normal and 8 asthmatic subjects afer s.c. and oral administration of terbutaline. Prior to the investigation, the patients had not used bronchodilators for 10-14 days. The finger tremor pattern showed a striking parallelism between the terbutaline serum concentrations and the cAMP plasma levels. After s.c. administration the increase in tremor values in asthmatic subjects was significantly less than in normals. This suggests a .beta.-blockade in skeletal muscle of asthmatics. The difference after oral administration was not statistically significant.